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The Clinical Researcher Knowledge Testing
Answer the questions below and then click the button. The next page will mark your answers and show you how well you have done compared with the previous people who have taken the tests.

Test Title:
Clinical Trial Design


Question Number 1:
What is the generally accepted minimum level of power for a clinical trial?
A
 50%
B
 60%
C
 70%
D
 80%

Question Number 2:
An analysis of trial data performed while the trial is ongoing is called?
A
 Supplementary Analysis
B
 Post-hoc Analysis
C
 Interim Analysis
D
 Tertiary Analysis

Question Number 3:
In a trial of treatment A compared to treatment B the results showed that in country 1 treatment A was better than treatment B and in country 2 treatment B was better than treatment A, What is this called?
A
 factor crossover
B
 treatment by country interaction
C
 non-consistent result
D
 ethnic origin effect

Question Number 4:
Which of the following most accurately describes "single blind"
A
 One of the products is a placebo
B
 There is only one treatment arm on the study
C
 Either the investigator or the subject know which product the subject is given but not both
D
 One of the products is blinded but the other one isn't

Question Number 5:
What does IVRS stand for
A
 Investigator Voice Resolution System
B
 Investigative Verification of Randomisation System
C
 Investigator Voice Randomisation System
D
 Interactive Voice Recognition System

Question Number 6:
If your sample size calculations gave you a required figure of 1000 patients in the trial and this was considered too high which of the following could reduce the sample size?
A
 Decrease the expected treatment difference between groups
B
 Increase the power
C
 Increase the variability estimate
D
 Reduce the power

Question Number 7:
Which of the following expected group response rates would require the largest sample size ensuring all other factors remained constant?
A
 A = 40%, B = 35%
B
 A = 30%, B = 25%
C
 A = 25%, B = 20%
D
 A = 20%, B = 15%

Question Number 8:
Which of the following could you use a cross-over design for?
A
 Measuring effectiveness of two flu vaccines
B
 Measuring survival time for two cancer treatments
C
 Measuring effectiveness of two pain relief products for the common headache
D
 Measuring effectiveness of two teeth whitening toothpastes

Question Number 9:
What is the name given to the area of trial design that uses the data that accumulates during the trial to decide how to modify specific aspects of the trial, for example combining a phase II dose selection study with a phase III confirmatory study?
A
 Combination Trial Design
B
 Adaptive Trial Design
C
 Modular Trial Design
D
 Efficient Trial Design

Question Number 10:
Which of the following would be an example of an adaptation to a trial?
A
 Increasing the sample size after review of interim data
B
 Reducing the sample size after review of interim date
C
 Removing and ineffective treatment arm and continuing other treatment arms
D
 All of the above

 

 

 

 

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